MEDRC projects have the advantage of insight from the technology, medical, and the business arenas, significantly increasing the chances that a device will fulfill a healthcare need as well as be profitable for companies supplying the solutions.

With a new trend toward increased healthcare quality, disease prevention, and cost-effectiveness, such a comprehensive enterprise is crucial and a doorway to improved healthcare practices nationwide.

MEDRC research projects are defined jointly by faculty, researchers, physicians, and clinicians, along with the Center’s industrial partners. A visiting scientist from a project’s sponsoring company, present at MIT, serves as the champion translator for bringing innovations back to the company for commercialization, providing the industrial viewpoint necessary to realize the needed technology.

Microfluidic Electronic Detection of Protein Biomarkers

We are developing an all-electronic immunoassay with which we can 1) achieve high-throughput, potentially measuring all protein biomarkers in blood samples; 2) reduce cost by taking advantage of the decreasing cost of silicon electronics; 3) deliver results to patients before they meet with their physicians.

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A Portable Bioimpedance Measurement System for Congestive Heart Failure Management

Bioimpedance measurements have been shown to be predictive of heart failure decompensation up to 14 days before an event occurs. We have developed a portable bioimpedance system that can measure body impedance from 1 kHz to 1 MHz. The system uses the Magnitude-Ratio and Phase Difference Detection method to calculate the magnitude and phase of the measured impedance.

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A Wearable Long-term Cardiac Monitor

Authors: Maggie Delano, Stanislav Yukashov, Charles Sodini

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Predicting Death After Acute Coronary Syndrome

Frequency domain measures of heart rate variability (HRV) are associated with adverse events after a myocardial infarction. However, because of natural variability in heart rate over time and across patients, patterns in the traditional “time-frequency” domain (measured in Hz) may capture different cardiac phenomena at different heart rates.

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Long-Term, Subdermal Implantable EEG Recorder and Seizure Detector

Epilepsy patients with infrequent seizures cannot come into the hospital for weeks on end in order for an event to be captured on EEG – a necessary prerequisite for making a definitive diagnosis, tailoring therapy, or even affixing the true rate of events. This work aims to solve this need by proposing a subdermal implantable 8-channel EEG monitor and seizure detector.

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