Microfluidic Electronic Detection of Protein Biomarkers
We are developing an all-electronic immunoassay with which we can 1) achieve high-throughput, potentially measuring all protein biomarkers in blood samples; 2) reduce cost by taking advantage of the decreasing cost of silicon electronics; 3) deliver results to patients before they meet with their physicians.
A Portable Bioimpedance Measurement System for Congestive Heart Failure Management
Bioimpedance measurements have been shown to be predictive of heart failure decompensation up to 14 days before an event occurs. We have developed a portable bioimpedance system that can measure body impedance from 1 kHz to 1 MHz. The system uses the Magnitude-Ratio and Phase Difference Detection method to calculate the magnitude and phase of the measured impedance.
Predicting Death After Acute Coronary Syndrome
Frequency domain measures of heart rate variability (HRV) are associated with adverse events after a myocardial infarction. However, because of natural variability in heart rate over time and across patients, patterns in the traditional “time-frequency” domain (measured in Hz) may capture different cardiac phenomena at different heart rates.
Long-Term, Subdermal Implantable EEG Recorder and Seizure Detector
Epilepsy patients with infrequent seizures cannot come into the hospital for weeks on end in order for an event to be captured on EEG – a necessary prerequisite for making a definitive diagnosis, tailoring therapy, or even affixing the true rate of events. This work aims to solve this need by proposing a subdermal implantable 8-channel EEG monitor and seizure detector.
An Electronically Steered, Wearable Transcranial Doppler (TCD) Ultrasound
While several non-invasive cerebrovascular diagnostic modalities exist, the use of transcranial Doppler (TCD) sonography is highly compelling for certain diagnostic needs due to its safety in prolonged studies, high temporal resolution, and relative portability.
Piezoelectric Micro-Machined Ultrasonic Transducers for Medical Ultrasound
Commercial realization of advanced medical ultrasound imaging trends will require cost effective, large scale arrays of miniaturized elements, which are expensive to fabricate using traditional bulk piezoelectric materials. At high volume, micro-fabricated transducers are an array compatible and low cost alternative.
Non-invasive Arterial Pressure Waveform Monitoring
An arterial blood pressure (ABP) waveform provides valuable information in treating cardiovascular diseases of patients. Ultrasonic ABP monitoring is preferable because of the potentially portable system implementation and its non-invasive nature, thus minimizing tissue damage and the possibility of infection.
Calibration-Free Blood Pressure Estimation Using Ultrasound
In this poster, an algorithm is developed to estimate blood pressure at the carotid artery in a way that is non-invasive, potentially continuous, easy-to-use, and calibration-free.